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Research Scientist Oxford About ExogeneAt Exogene, we’re reimagining what’s possible in cancer im... Research Scientist Oxford About ExogeneAt Exogene, we’re reimagining what’s possible in cancer immunotherapy. Our mission is to engineer T-cell receptor therapies that can precisely and powerfully target advanced solid tumours.To do this, we’ve built a proprietary lab-in-the-loop platform that merges generative AI, biophysical modelling, and high-throughput TCR screening to rapidly design, test, and optimise TCRs with exceptional affinity and specificity. This convergence of computation and wet-lab experimentation allows us to go from concept to candidate molecules in record time.We’re developing TCR-based trispecific T cell engagers (TCR-TriTCEs)—a new therapeutic modality designed to overcome the unique challenges of the solid tumour microenvironment. This work spans multiple disciplines, from protein engineering and AI-driven design to in vivo validation and translational development.We are looking for a dynamic research scientist who will help drive the TCR engineering processes and development. The successful candidate will contribute to in vivo and in vitro validation of TCEs. You’ll get involved in purifying recombinant TCRs to perform high-throughput TCR display methods and deep sequencing.Responsibilities Contribute to in vivo and in vitro validation of TCEs.Collaboratively design and characterise TCRs for proprietary and partnered disease targets.Conduct a suite of protein science operations, including expression, purification, and biophysical analysis.Tackle molecular biology duties: cloning, mutagenesis, DNA isolation, and preparing libraries for deep sequencing.Manage tissue culture assignments, spanning from media prep and cell line care to cryopreservation.Join forces with founders, R&D, academia, and industrial stakeholders to fulfil ambitious R&D objectives.Draft, revise, and oversee repertoire of lab protocols.Offer essential lab support and uphold facility upkeep. Skills and Qualifications PhD in Immunology, Cell Biology, Biochemistry, or an alike field, paired with at least 1-2 years of relevant lab experience is required.Knowledge of molecular biology protocols, with an emphasis on cloning and PCR is preferred.A background in molecular biology, protein expression, purification and biophysical characterisation is preferred.Experience in cell and immunological assays (flow cytometry, ELISA etc.) is desired.Experience with in vivo and in vitro validation of TCEs (T-cell engagers) in some or all aspects of investigational new drug (IND) approval is desired.Experience TCR engineering is desired.SOP documentation experience is desired.The highest standards in lab precision, record maintenance, and documentation.Excellent written and oral communication skills. Attributes Self-starter with sound analytical skills, who values scientific integrity and novelty.Collaborative spirit within the lab, open to both giving and receiving actionable feedback.Exceptional at diagnosing and overcoming unforeseen technical challenges.Adept at juggling and prioritising multiple projects to meet deadlines.Versatile and efficient within an interdisciplinary, fast-paced team setup. What We Offer Market-competitive salary and stock option package.A generous leave policy: 25 days holiday, public holidays, plus a day off for your birthday!Access to fully equipped private lab.Flexibility to work from home as project demands allow.A supportive, cross-disciplinary team fostering a highly collaborative work environment. How to apply Launch your journey with Exogene by submitting your CV and a brief cover letter (maximum 400 words) to m.hasan at exogene.co.uk

Recruit4staff is proud to be representing their client, a leading Wrexham-based pharmaceutical manuf... Recruit4staff is proud to be representing their client, a leading Wrexham-based pharmaceutical manufacturer, in their search for a Science Graduate to join their state-of-the-art production facility.For the successful Science Graduate, our client is offering: £16.21 per hour (including shift allowance) Monday to Friday, Days role, typically 7 am - 3 pm; however, flexibility will be requiredTemporary ongoing role with the potential to go permanent for the right candidate Training and development opportunities Free parking on-site Excellent working conditions  The role – Science Graduate: Assist in the full end-to-end pharmaceutical manufacturing process, supporting both upstream and downstream operations.Operate process equipment including vial filling, lyophilisation, and capping machinery.Carry out basic preventive maintenance, cleaning, and equipment setup duties.Monitor output and quality, completing all documentation to GMP standards using SOPs and logbooks.Maintain a safe and compliant workspace, contributing to inspection readiness and internal audits.Participate in continuous improvement and lean manufacturing initiatives.Support environmental and utility monitoring (e.g. WFI sampling and alarm response). What our client is looking for in a Science Graduate: A recent Science Degree (ideally in Biology, Chemistry, or related) – ESSENTIALStrong understanding or willingness to learn aseptic processes and GMP standardsKeen interest in pharmaceutical manufacturing – ESSENTIALExcellent attention to detail and ability to follow strict proceduresStrong written and verbal communication skillsMust be immediately available with no significant upcoming holidays that will impact training - ESSENTIAL Key Skills or Similar Job Titles: Science Graduate, Biology Graduate, Chemistry Graduate, Process Technician, Pharmaceutical Manufacturing Technician, Graduate GMP OperatorCommutable From: Wrexham, Chester, Oswestry, Mold, Deeside, Ellesmere Port, Whitchurch, ShrewsburyFor further information about this and other positions, please apply now.This vacancy is being advertised on behalf of Recruit4staff (Wrexham) Ltd, who are operating as a recruitment agency, agent, agencies, employment agency, or employment business.